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Updated: Jun 17, 2025

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阻断剂-SELEX:一种以结构为导向的策略,用于开发抑制性亚胺,以破坏无法治疗的转录因子相互作用

Tongqing Li1,2, Xueying Liu1, Haifeng Qian1

  • 1Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China.

Nature communications
|August 8, 2024
PubMed
概括

抑制性受体 (iAptamers) 提供了一种针对疾病转录因子 (TFs) 的新方法. 这种新方法,Blocker-SELEX,成功地破坏了关键的TF相互作用,影响了基因表达和细胞生长.

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