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Updated: Jun 17, 2025

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
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托尔辛A对神经元核毛孔复合物的局部化和成熟至关重要

Sumin Kim1,2,3, Sébastien Phan4, Hung Tri Tran5,6

  • 1Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA.

Nature cell biology
|August 8, 2024
PubMed
概括

在发育中的神经元中,TorsinA蛋白对于组织核孔综合体 (NPC) 至关重要. 它的功能障碍破坏了NPC局部化,影响神经元发育,并可能导致神经发育障碍.

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
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