细胞因子风暴综合征的实验室特征和病理学
Flavia G Rosado1, Purva Gopal2
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Advances in experimental medicine and biology
|August 8, 2024
概括
诊断细胞因子风暴综合征 (CSS),如血细胞淋巴细胞细胞瘤 (HLH) 和巨细胞激活综合征 (MAS),是困难的. 本综述涵盖了CSS的发病,实验室发现和诊断方法,以改善临床管理.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 临床病理学 临床病理学
背景情况:
- 细胞因子风暴综合征 (CSSs),包括血细胞淋巴细胞细胞瘤 (HLH) 和巨细胞激活综合征 (MAS),在临床实践中构成重大诊断挑战.
- 常规可用的CSS诊断实验室测试往往缺乏特异性,使早期和准确的识别复杂化.
- 对于CSS的潜在疾病机制,特别是在成年人群中,仍然不完全理解.
研究的目的:
- 审查细胞因子风暴综合征 (CSSs) 的致病性.
- 详细说明与CSSs相关的实验室发现.
- 概述为CSSs推的诊断策略,解决目前的局限性.
主要方法:
- 文献综述侧重于病变发生,实验室诊断和CSSs的临床管理.
- 关于血细胞淋巴细胞细胞瘤 (HLH) 和巨细胞激活综合征 (MAS) 的信息综合.
- 对CSS检测的诊断标准和实验室测试实用性的分析.
主要成果:
- 由于标准测试的非特异性发现,CSSs的实验室诊断具有挑战性.
- 在许多地区,包括美国,CSS的确认诊断测试并未得到广泛的访问.
- 对于CSS病原体的理解,特别是在成年人中,仍在不断发展.
结论:
- 有效的CSSs实验室诊断需要全面的方法,整合临床和不断发展的实验室数据.
- 需要改进的诊断策略来克服CSSs当前实验室测试的局限性.
- 对CSS病变的进一步研究对于开发更具体的诊断标记物和向疗法至关重要.
关键词:
CD163 是一个CD163 CD163 是一个CD163CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25费里胺是一种铁素.血细胞灭菌症 (hemophagocytosis) 是一种导致血细胞灭菌症的疾病.在 NK 细胞中, NK 细胞是最重要的.更多相关视频
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