动物感染的细菌感染引发细胞因子风暴综合征
Zaher K Otrock1, Charles S Eby2
1Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, MI, USA. zotrock1@hfhs.org.
Advances in experimental medicine and biology
|August 8, 2024
概括
动物感染的细菌感染可以导致严重的血细胞淋巴细胞瘤 (HLH),也称为细胞因子风暴综合征 (CSS). 早期识别发烧和低血细胞计数等症状对于管理这些危及生命的疾病至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 动物传播感染对健康构成重大风险,有可能导致严重的全身并发症.
- 血细胞淋巴细胞细胞瘤 (HLH) 和细胞因子风暴综合征 (CSS) 是危及生命的超炎症性疾病.
- 细菌病原体经常与导致HLH/CSS的动物性感染有关.
研究的目的:
- 突出动物性细菌感染与HLH/CSS之间的关联.
- 审查导致HLH/CSS的细菌病原体的谱.
- 概述这些感染的常见临床表现.
主要方法:
- 对与HLH/CSS相关的动物性细菌感染的文献综述.
- 对受影响患者报告的临床表现的分析.
主要成果:
- 细菌是与动物性传染病相关的HLH最常见的原因.
- 涉及的关键细菌物种包括Brucella spp.,Rickettsia spp.,Ehrlichia,Coxiella burnetii,Mycobacterium spp.和Bartonella spp.这些细菌物种被认为是主要的.
- 常见的症状包括发烧,细胞衰竭和肝炎;皮疹,黄和淋巴腺病变不太常见.
结论:
- 动物传染性细菌感染是HLH/CSS的关键原因,但往往未得到充分承认.
- 及时诊断和管理对于改善患者的治疗结果至关重要.
- 对于临床医生来说,对致病原体和临床症状的认识至关重要.
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