经过带切除术后局部用美特罗尼达来减轻术后疼痛:一个系统性审查
Chiara Eberspacher1, Domenico Mascagni2, Stefano Pontone2
1Department of Surgery, University of Rome "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy. chiara.eberspacher@gmail.com.
Updates in surgery
|August 8, 2024
概括
与安慰剂相比,局部用美트로尼达在切除性出血栓切除术后有效降低了术后疼痛. 然而,它没有显著的优势比口服甲尼达醇,在两种给药途径的并发症最小.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 切除性出血切除术是出血的标准治疗方法,通常会导致严重的术后疼痛.
- 管理这种疼痛对于患者的康复和满意度至关重要.
- 口服甲尼达已在减轻疼痛方面表现出有效性,但具有潜在的并发症.
研究的目的:
- 系统地审查局部美特罗尼达在切除性淋病切除术后治疗术后疼痛的疗效.
- 为了比较局部甲尼达与安慰剂和口服甲尼达配方的有效性.
- 评估局部服药对口服方式的潜在优越性.
主要方法:
- 一个系统审查的随机对照试验 (RCTs) 发表到2023年9月.
- 在PubMed,Central和Web of Science数据库中进行的搜索.
- 主要结局:术后疼痛 (视觉模拟量表);次要结局:止痛药的使用,恢复工作,并发症.
主要成果:
- 包括6项涉及536名患者的RCT.
- 与安慰剂相比,局部用美트로尼达在减少术后疼痛方面表现出有效性.
- 在局部和口服美트로尼达之间没有观察到疼痛减轻的显著差异.
- 对于局部和口服的甲尼达配方,并发症是最小的.
结论:
- 局部和口服的甲尼达都在切除性切除术后的术后疼痛管理中有效.
- 目前的证据不支持一种给药途径对另一种药物显著优越.
- 在这种情况下,需要进一步的研究来确定最佳的甲尼达用于疼痛管理.
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