长期COVID-19 (SE-LC19) 的症状演变:一个新的患者报告内容有效仪器
Diana Rofail1, Selin Somersan-Karakaya2, Eleftherios Mylonakis3,4
1Regeneron Pharmaceuticals, Inc., 1 Rockwood Road, Sleepy Hollow, NY, 10591, USA. diana.rofail@regeneron.com.
Journal of patient-reported outcomes
|August 8, 2024
概括
一个新的患者报告结果仪器,长期COVID-19 (SE-LC19) 的症状演变,被开发和验证. 该工具有助于评估长期的COVID症状和恢复,解决不断发展的研究中的关键需求.
科学领域:
- 医学研究 医学研究
- 患者报告的结果
- 纵向健康研究 纵向健康研究
背景情况:
- 评估和监测长期COVID症状和康复的工具有限.
- 长期COVID研究领域需要强大的患者评估工具.
研究的目的:
- 开发一种新的患者报告结果仪器,即长期COVID-19的症状演变 (SE-LC19).
- 确定SE-LC19仪器用于评估长期COVID症状的内容有效性和适用性.
主要方法:
- 使用文献和临床指南创建了一个40项SE-LC19仪器.
- 通过对41名长期COVID患者和5名临床医生进行定性访谈来评估内容的有效性.
- 探索性拉什测量理论 (RMT) 分析评估了心理特征.
主要成果:
- 患者和临床医生发现SE-LC19仪器是全面和相关的.
- 患者报告的轻微概念差距和7天回忆期的建议被注意到.
- 探索性RMT分析证实了SE-LC19问卷按预期执行.
结论:
- SE-LC19仪器证明了内容的有效性和适用于评估长期COVID症状的适用性.
- 需要进一步的研究来探索心理测量特性,并改进SE-LC19作为患者相关的终点.
- SE-LC19有可能用于临床试验和实践,以追踪长期COVID的发病,严重程度和恢复.
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