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设计出新生的活人组织,具有单元可编程性

Pedro Lavrador¹, Beatriz S Moura¹, José Almeida-Pinto¹

¹CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal.

Nature materials

|August 8, 2024

概括

研究人员将人体细胞改造成生物材料,称为细胞凝. 这些可编程的Cellgels可以自组装成复杂的3D结构,模仿自然组织并促进伤口愈合.

科学领域:

生物材料工程生物材料工程
组织工程是组织工程.
合成生物学合成生物学

背景情况:

生物材料为高级应用提供独特的功能和可编程性.
目前用于创建细胞结构的方法在可扩展性和生物集成方面存在局限性.

研究的目的:

开发一种用于制造具有可控制性质的人类生活材料的新平台.
证明这些生物材料在模仿组织接口和促进再生过程方面的潜力.

主要方法:

人类细胞的代谢工程,以表达结合糖蛋白.
将工程细胞组装成具有高细胞密度的三维细胞凝.
细胞凝的机械性能,可操作性和生物功能的表征.

主要成果:

成功创建了Cellgels,这是人类生活材料的新类别,具有可调节的特性和高细胞密度 (高达10^8细胞/厘米3).
证明了自主组织整合,机械成熟,自我愈合和促进伤口愈合.
启用了模块化组装的多尺度构造,类似于异质的人体组织接口.

结论:

细胞凝代表了一个多功能平台,可以从人类细胞中制造可编程的生物材料.
细胞凝的固有生物能力使其在再生医学和组织工程中的应用成为可能.
这项技术有可能在各种人类细胞类型中广泛应用,用于创建先进的生物材料.

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