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ASL,DSC,DCE输液MRI和18F-DOPA PET/CT在区分质瘤复发与治疗后的变化方面

Giulia Moltoni¹, Andrea Romano², Gabriela Capriotti³

¹NESMOS, Department of Neuroradiology, S. Andrea Hospital, University Sapienza, Via di Grottarossa 1035/1039, 00189, Rome, Italy. giulia.moltoni@uniroma1.it.

La Radiologia medica

|August 8, 2024

概括

区分质瘤复发与治疗效应是很困难的. 动脉旋转标记 (ASL) MRI是最有效的技术,在识别真正的瘤复发方面,其表现优于其他MRI方法和18F-DOPA PET/CT.

科学领域:

神经瘤学神经瘤学
医学成像医学成像
放射学放射学是一门学科.

背景情况:

区分治疗后的变化和手术和化疗辐射后的质瘤复发是临床上具有挑战性的.
新增强性病变需要准确的评估来指导患者的管理.

研究的目的:

为了评估动脉脊柱标记 (ASL),动态敏感性对比 (DSC) 和动态对比增强 (DCE) perfusion MRI 的诊断性能,以及 18F-DOPA PET/CT.
为了区分瘤复发与治疗后的变化在患有质瘤的患者.

主要方法:

治疗质瘤和新的,模两可的增强性病变的患者的未来招募.
获得1.5TMRI,包括ASL,DSC,DCE输液和18F-DOPA PET/CT.
分析ASL衍生的脑血流 (CBF) 和正常化的CBF (nCBF),DSC衍生的相对脑血量 (rCBV),DCE参数 (Ktrans,Vp,Ve,Kep) 和PET衍生的SUVmax.
通过临床和放射学随访证实了诊断.

主要成果:

分析了29种病变 (5种低级,24种高级质瘤);14种是复发性瘤,15种是治疗后的变化.
无变物流回归表明ASL (CBF,nCBF),DSC (rCBV) 和PET (SUVmax) 与瘤复发有关.
多变量逻辑回归确定了ASL的正常化CBF作为瘤复发的唯一显著预测因子 (p=0.008,OR=22.85).

结论:

与DSC,DCE perfusion MRI和18F-DOPA PET/CT相比,动脉脊柱标记 (ASL) 显示出更高的性能.
在这个患者队列中,ASL是最有效的成像技术,用于区分结质瘤复发与治疗后的变化.

关键词:

质瘤是一种质瘤.磁力共振成像 (MRI) perfusion perfusion 透方式磁力共振成像 (MRI) perfusion 透方式在这里,PET是PET.治疗后发生的变化.瘤复发的情况

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