Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

1.2K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
1.2K
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

2.1K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
2.1K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

4.9K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
4.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells.

Communications biology·2026
Same author

AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes.

bioRxiv : the preprint server for biology·2026
Same author

A loss of function variant in <i>SLC30A8/ZnT8</i> drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets.

medRxiv : the preprint server for health sciences·2026
Same author

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations.

The Journal of general physiology·2026
Same author

Stephen Ashcroft, 27 January 1942-28 November 2025.

Diabetologia·2026
Same author

MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 17, 2025

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis
07:58

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

1.6K

探索胰腺β细胞子组及其连接性.

Guy A Rutter1,2,3, Anne Gresch4, Luis Delgadillo Silva5

  • 1CHUM Research Center and Faculty of Medicine, University of Montréal, Montréal, QC, Canada. g.rutter@imperial.ac.uk.

Nature metabolism
|August 8, 2024
PubMed
概括

胰腺β细胞形成了一个对葡萄糖平衡至关重要的网络. 这项研究探讨了这个网络中的层次结构,确定了控制胰岛素分泌的关键β细胞群体,并且可能在糖尿病中失败.

更多相关视频

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
05:38

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

12.2K
Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
11:34

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

Published on: July 18, 2019

16.4K

相关实验视频

Last Updated: Jun 17, 2025

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis
07:58

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

1.6K
Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
05:38

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

12.2K
Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
11:34

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

Published on: July 18, 2019

16.4K

科学领域:

  • 内分泌学 在内分泌学.
  • 细胞生物学 细胞生物学
  • 系统生物学 系统生物学

背景情况:

  • 功能性胰腺小岛β细胞对于葡萄糖平衡至关重要.
  • 在小岛内存在显著的细胞异质性,网络连接影响胰岛素的释放.

研究的目的:

  • 讨论关于岛内连接和β细胞层次结构的当前理解和辩论.
  • 探索研究人类和动物小岛制剂的方法.
  • 为了确定控制动态和胰岛素分泌的关键β细胞子组.

主要方法:

  • 不同细胞制剂的比较 (体外和体内).
  • 人类和动物小岛制剂的成像和活动控制.
  • 对活细胞数据的分析方法,以确定功能细胞子组.

主要成果:

  • 根据反应,识别潜在的"控制"β细胞群体,如"第一响应者"",领导者"和"枢纽".
  • 讨论贝塔细胞层次组织的基础机制.
  • 在糖尿病中考虑生理相关性和层次的丧失.

结论:

  • 岛内连接和细胞层次在调节胰岛素分泌方面发挥着至关重要的作用.
  • 了解这些层次结构对于理解糖尿病中小岛功能和失败至关重要.
  • 先进的分析方法是剖析复杂β细胞网络动态的关键.