基于质磨损的临床相关衰老模型的验证
Beshr Hajhamid1, Laurent Bozec1, Hassan Moghadam2
1Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
概括
新的体外老化模型模拟了人类牙磨损,比较了临床研究中的生理和侵蚀性磨损数据. 开发的模型显示了与体内测量结果一致的结果,有助于未来的研究.
科学领域:
- 牙科的生物材料.
- 磨损模拟器的使用
- 乳的侵蚀侵蚀导致了乳的侵蚀.
背景情况:
- 临床研究报告了生理和侵蚀性牙磨损的显著差异.
- 精确模拟体内牙磨损对于材料开发和临床评估至关重要.
研究的目的:
- 审查现有的关于生理和侵蚀性牙磨损的临床数据.
- 开发和验证模拟口腔挑战的新型体外衰老模型.
- 将这些模型的磨损数据与临床发现进行比较.
主要方法:
- 进行了对牙磨损临床研究的系统审查.
- 开发了两个体外老化模型:一个模拟机械和热挑战 (MT),另一个模拟机械,热和酸性挑战 (MTA).
- 标本经历了各种,热变化和酸暴露的周期.
主要成果:
- 该评论分析了13项临床研究,估计年平均生理性磨损为38.4微米,侵蚀性磨损为179.5微米.
- MT1模型 (24万次,1万次热循环) 导致60微米的磨损.
- MTA1模型 (24万次,1万次热,3小时酸性循环) 导致209微米的磨损,与临床侵蚀性磨损估计非常相符.
结论:
- 牙磨损的临床数据显示出相当大的变异性,突出了需要先进的研究方法的需求.
- 开发的体外衰老模型 (MT和MTA) 提供了与体内牙磨损相一致的结果.
- 这些新型模型显示了准确模拟和研究生理和侵蚀性牙磨损的前景.
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