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Updated: Jun 17, 2025

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

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洞察Pyridines和Quinolines的光驱C-H基化中的C4选择性

Leejae Kim1,2, Wooseok Lee1,2, Sungwoo Hong1,2

  • 1Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, 34141, Republic of Korea.

Angewandte Chemie (International ed. in English)
|August 9, 2024
PubMed
概括

这项研究引入了一种新的以光驱动的方法,用于选择性基化二烯和二烯. 该方法使用易于获得的硫酸盐实现了高C4区域选择性,使得各种类药物分子的合成成为可能.

关键词:
在EDA复杂的EDA系统中.醇基化法 醇基化法异循环的不同循环.光化学反应是光化学反应.地区选择性 地区选择性

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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Selection Rules: Photochemical Activation
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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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