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Updated: Jun 17, 2025

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第一次性交时的年龄,初潮时的年龄和更年期时的年龄:关于肺癌风险的门德尔随机化研究
Yifan Liu1, Xinxin Ying1, Yao Li1
1Department of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Translational lung cancer research
|August 9, 2024
概括
晚年第一次性交 (AFS) 与整体肺癌,肺腺癌和肺状细胞癌的风险降低有关. 这凸显了性教育和早期干预对生殖健康的重要性.
科学领域:
- 生殖健康和瘤学
- 遗传流行病学遗传流行病学
- 激素对癌症的影响
背景情况:
- 性激素与肺癌的发展有关,但生殖行为与肺癌风险之间的联系尚不清楚.
- 之前关于生殖因素和肺癌风险的研究已经产生了不一致的结果.
- 诸如第一次性交 (AFS) 的年龄,初潮的年龄和更年期的年龄等生殖行为会影响性激素水平.
研究的目的:
- 使用孟德尔随机化 (MR) 方法调查关键生殖行为与肺癌风险之间的潜在因果关系.
- 专门研究AFS,初潮时的年龄和更年期时的年龄与整体肺癌 (LUCA) 和其亚型 (LUAD,LUSC,SCLC) 的相关性.
主要方法:
- 进行了两样本的孟德尔随机化 (MR) 分析,使用来自欧洲祖先的全基因组关联研究 (GWAS) 数据.
- 逆变量加权是MR分析的主要方法,灵敏度分析包括MR-多变性残余和异常值,加权中位数,MR-Egger和留出一个分析.
- 该研究评估了AFS,初潮年龄和更年期年龄对LUCA,LUAD,LUSC和SCLC的独立影响.
主要成果:
- 在第一次性交 (AFS) 时的年龄较大显示出与整体肺癌 (LUCA) 风险降低的显著因果关系.
- 较老的AFS也与较低的肺腺癌 (LUAD) 和肺状细胞癌 (LUSC) 风险有关.
- 在这项分析中,对于初潮时的年龄或更年期时的年龄与肺癌风险没有发现显著的因果关系.
结论:
- 这些发现表明,在第一次性交时的晚年可能有保护作用,防止患上肺癌.
- 结果强调了全面性教育的重要性,强调了早期性活动的潜在不良影响.
- 建议与生殖健康教育一起提供早期心理支持和干预.
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