确定与MAFLD相关的最关键的行为生活方式:来自NHANES 2017-2020年的证据
Sicheng Li1, Jiajin Chen1, Yuqin Zhang2
1Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Frontiers in endocrinology
|August 9, 2024
概括
这项研究发现,睡眠时间,体力活动 (MET) 和饮食质量 (HEI-2015) 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有关. 身体活动是预防MAFLD最有影响力的生活方式因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 越来越多地与生活方式因素有关.
- 多种生活方式暴露对MAFLD风险的综合影响尚不清楚.
- 针对MAFLD的有针对性的预防策略需要了解联合生活方式的影响.
研究的目的:
- 调查生活方式暴露和MAFLD之间的联合关联.
- 确定导致MAFLD的主要生活方式因素.
- 评估潜在的人口层面干预效益.
主要方法:
- 从NHANES 2017-2020中对5,002名参与者的分析.
- 对生活方式暴露的评估:睡眠时间,体力活动 (MET),饮食质量 (HEI-2015),酒精和吸烟.
- 使用过渡性弹性素和实验室数据进行MAFLD诊断.
- 后勤回归和加权定量总和方法用于单个和联合暴露分析.
主要成果:
- 增加睡眠时间,MET和HEI-2015分数与减少MAFLD风险有关.
- 睡眠,MET和HEI-2015的联合暴露与MAFLD有显著的关联.
- 身体活动 (MET) 成为联合暴露模型中最有影响力的因素.
结论:
- 包括睡眠,饮食和体育活动在内的生活方式因素与MAFLD有显著的关联.
- 身体活动被认为是预防MAFLD的关键因素.
- 人口益处分析表明,针对睡眠,饮食和体育活动进行量身定制的干预措施.
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