循环的Isthmin-1与孤立的挑战后高血糖症的性别特异关联
Jiahua Fan1,2,3, Jialin He2,3, Jiangyuan Zhu2,3
1Department of Clinical Nutrition, Guangzhou Chest Hospital, Guangzhou, Guangdong, China.
Frontiers in endocrinology
|August 9, 2024
概括
伊斯敏-1 (ISM1) 是一种潜在的生物标志物,用于识别患有孤立挑战后高血糖症 (IPH) 高风险的男性. 更高的ISM1水平与男性IPH的可能性降低有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 生物标志物发现发现
背景情况:
- 孤立的挑战后高血糖症 (IPH) 是2型糖尿病的前体.
- 早期识别IPH风险的个体对于及时干预至关重要.
- 伊斯敏-1 (ISM1) 在葡萄糖代谢中的作用及其与IPH的关联需要进一步研究.
研究的目的:
- 在接受口服葡萄糖耐受性测试的人群中调查伊斯敏-1 (ISM1) 水平的分布.
- 确定ISM1水平与孤立的挑战后高血糖症 (IPH) 之间的关联.
- 评估ISM1作为早期IPH风险检测的潜在生物标志物,特别是在男性中.
主要方法:
- 一组522名没有糖尿病病史的参与者接受了75克2小时口服葡萄糖耐受性测试 (OGTT).
- 用HOMA和OGTT衍生的估计来评估胰岛素敏感性和β细胞功能.
- 使用商业ELISA套件量化了循环中的ISM1水平.
主要成果:
- 76名参与者 (14.6%) 被诊断患有IPH,占新的糖尿病病例的61.3%.
- 男性的ISM1水平明显高于女性.
- 在男性中观察到ISM1和β细胞功能/IPH之间的反向相关性,较高的ISM1水平显著降低了IPH的几率.
- 将ISM1集成到风险得分中可以改善IPH预测.
结论:
- 伊斯敏-1 (ISM1) 显著且独立地与孤立的挑战后高血糖症 (IPH) 相关.
- ISM1显示出作为可行的生物标志物的潜力,用于早期识别IPH高风险男性.
- 这些发现凸显了ISM1在葡萄糖失调中的作用及其在风险分层中的临床实用性.
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