体重轨迹与24个月后神经发育结果之间的关联在出生体重非常低的早产婴儿中经过年龄校正:基于小组的轨迹建模研究
Ts-Ting Wang1,2, Yen-Ju Chen2, Yi-Han Su2
1Department of Pediatrics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Frontiers in pediatrics
|August 9, 2024
概括
在出生时体重非常低 (VLBW) 的婴儿中,体重的低下降轨迹和囊性周周膜瘤白血病 (cPVL) 与神经发育障碍有关. 早期体重模式和健康状况预测了VLBW婴儿的后期结果.
科学领域:
- 新生儿科学 新生儿科学
- 发育儿科 发育儿科
- 公共卫生 公共卫生
背景情况:
- 非常低出生体重 (VLBW) 的婴儿面临不良神经发育结果的风险.
- 监测生长轨迹对于识别有风险的婴儿至关重要.
研究的目的:
- 研究从出生到6个月的正确年龄 (CA) 的体重 (BW) z-score轨迹与VLBW婴儿在24个月CA时的神经发育结果之间的关联.
- 为了确定预测神经发育障碍 (NDI) 的特定体重模式.
主要方法:
- 在21家台湾医院对3334名VLBW婴儿 (怀孕23-32周) 进行了基于人口的回顾性队列研究.
- 基于组的轨迹建模确定了不同的BWz-score轨迹.
- 多变量逻辑回归分析了轨迹,产后并发症 (包括囊性周周膜瘤白血病-cPVL) 和24个月CA后的NDI之间的关联.
主要成果:
- 确定了三种不同的BWz-score轨迹:高,中下降和低下降.
- 一个低下降的轨迹与NDI显著相关 (aOR:2.59;p < 0.001).
- 囊性周周垂体白血病 (cPVL) 也与NDI强烈相关 (aOR: 3.59; p < 0.001).
结论:
- 从出生到6个月的低体重下降轨迹CA是VLBW婴儿神经发育障碍的重要预测指标.
- cPVL的存在进一步增加了NDI的风险.
- 监测早期体重增加模式和解决CPVL等疾病对于改善VLBW婴儿的神经发育结果至关重要.
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