腹腔体积不对称作为一种新的成像生物标志物,用于疾病歧视和预测结果
Celeste McCracken1, Liliana Szabo2,3,4, Zaid A Abdulelah2
1Division of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
European heart journal open
|August 9, 2024
概括
心室不对称性,即偏离正常对称性,表明心血管风险. 左心室主导增加了心力衰竭的风险,而右心室主导与死亡率有关.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 公共卫生 公共卫生
背景情况:
- 心脏结构对称性对于功能至关重要.
- 腹腔对称度的偏差可能是心血管疾病风险的信号.
- 了解心室不对称分布是风险分层的关键.
研究的目的:
- 为了定义心室不对称的群体分布.
- 为了研究心室不对称性和心肺呼吸系统疾病之间的关系.
- 评估心血管风险评估中心室不对称的增量值.
主要方法:
- 用心血管磁共振 (CMR) 分析了44796名英国生物库参与者.
- 心室不对称度量化为左心室和右心室末端透缩体积的比.
- 通过回归模型检查与风险因素的关联,CMR特征以及心血管疾病的流行/发病情况.
主要成果:
- 左心室主导与血管风险因素,常见的心血管疾病和心力衰竭,心肌病和门疾病风险增加有关.
- 右心室主导与高死亡风险有关.
- 在健康子集中定义的腹腔对称性的正常范围.
结论:
- 心室不对称性为心血管风险评估提供了有价值的临床信息.
- 该指标提供了超越传统风险因素和传统CMR措施的洞察力.
- 心室不对称性是心血管不良结果的重要,独立的预测因素.
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