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一个与调节器相关的分类器用于肝细胞癌的预后和瘤微环境特征

Shaohua Xu^1,2, Yi Zhang¹, Ying Yang¹

¹Department of Clinical Laboratory, Center for Gene Diagnosis & Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, China.

Frontiers in immunology

|August 9, 2024

概括

对于预测肝肝细胞癌 (HCC) 瘤微环境 (TME) 和预后而言,mRNA N6-甲基氨酸 (m6A) 修饰模式至关重要. 根据预后,免疫类型和药物治疗,m6A风险评分为分层HCC患者提供了临床实用性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

mRNA N6-甲基氨酸 (m6A) 修饰在瘤发生中起着重要作用.
瘤微环境 (TME) 和肝肝细胞癌 (HCC) 免疫透对m6A调节者的影响仍未得到充分研究.

研究的目的:

调查m6A监管机构在HCC TME塑造中的作用.
为HCC患者开发基于m6A修饰模式的预后模型.

主要方法:

使用来自TCGA-LIHC和ICGC-LIRI-JP数据库的RNA测序数据.
雇员共识集群,WGCNA,LASSO,RF和SVM-RFE以确定m6A监管者并构建一个m6A风险评分模型.
评估了m6A风险得分与免疫特征,包括免疫细胞和检查点之间的相关性.

主要成果:

确定了两种不同的m6A修饰模式,与不同的临床结果和生物功能相关.
m6A风险评分模型显示出出色的预后性能,与临床结果,药物敏感性和免疫透相关.
纳入m6A风险评分和临床病理特征的诺莫图显示出对HCC预后的良好临床适用性.

结论:

m6A修饰模式对于预测HCC TME状态和患者预后至关重要.
m6A风险评分是预后分层,免疫类型和HCC药物治疗指导的宝贵工具.

关键词:

DCA DCA 的意思是什么?拉索·拉索 (Lasso) 是一个这是一种N6-甲基氨酸.在SVM-RFE中使用SVM-RFE.这就是TIICs.在WGCNA中,WGCNA是WGCNA.共识聚类算法共识聚类算法

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