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Updated: Jun 17, 2025

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设计,合成和生物评估diarylpyrimidine衍生物作为新型微管不稳定剂

Yutao Xiu1,2, Yujing Zhang3, Shanbo Yang1,2

  • 1Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.

Frontiers in chemistry
|August 9, 2024
PubMed
概括

新的二甲基胺衍生物被开发为抑制微管聚合的抗癌剂. 化合物11s通过破坏蛋白有效向癌细胞,为新型癌症药物发现提供了一个有前途的战略.

关键词:
它们具有抗增殖活动的抗增殖活性.结合列他A-4微管不稳定剂微管不稳定剂分子对接的分子对接.皮里米丁胺是一种

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