在患有乙性食道炎的儿童中,随着食物的重新引入,巨细胞的差异性变化
Andrew Ebanks1, Ming-Yu Wang1, Natalie Hoffmann1
1Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago, Box 65, Chicago, IL 60611, United States.
Journal of leukocyte biology
|August 9, 2024
概括
在性食道炎 (EoE) 中,四种食物消除饮食减少了巨细胞 (MCs). 牛奶的重新引入在儿童中独特地增加了食道MCs和炎症标志物,这表明牛奶在EoE病变发生过程中发挥了特定的作用.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 组织病理学 组织病理学
背景情况:
- 内皮质巨细胞 (MCs) 在性食道炎 (EoE) 中升高,并且随着饮食中抗原的消除而减少.
- 鉴定EoE内皮质巨细胞症的特定食物触发因素至关重要,但尚未完全理解.
研究的目的:
- 调查特定的食物是否对儿科EOE患者的内皮质巨细胞 (MC) 数量产生差异性影响.
- 在食品重新引入过程中,评估MCs和EoE的各种炎症和结构标记之间的相关性.
主要方法:
- 在基线,在4食物消除饮食 (4FED) 后,以及在重新引入期间,从儿科EoE队列中分析食道活检.
- 试酶染色以量化内皮质巨细胞 (MCs) 和与乙,基底细胞增生 (BCH),内镜检测结果,症状和粘膜活动得分的相关性.
主要成果:
- 这种四种食物消除饮食显著减少了内皮质MCs.
- 重新引入小麦增加了上食道MCs,特别是在eosinophilia.
- 牛奶的重新引入显著增加了整个食道的MCs,与乙,内镜异常,BCH和症状相关.
结论:
- 通过饮食消除抗原有效地减少了儿科EOE的乳腺腺细胞.
- 牛奶似乎在EoE患者的食道中独特地驱动杆细胞激活和炎症,与多种疾病指标相关.
- 需要进一步研究牛奶在EoE病原发生的具体机制.
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