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银化物Re通过抑制AMPKα1/STING正反循环诱导的巨细胞M2极化来抑制非小细胞肺癌的进展

Xiaoyu Tang^1,2, Man Zhu^1,2, Zeren Zhu^1,2

¹School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.

Phytotherapy research : PTR

|August 9, 2024

概括

银化物Re抑制非小细胞肺癌 (NSCLC) 巨细胞中的AMPKα1/STING反循环,减少M2极化和转移. 这项研究揭示了NSCLC免疫疗法的新疗法策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

非小细胞肺癌 (NSCLC) 的瘤相关巨细胞 (TAM) 促进转移.
金色化物 Re 通过调节免疫系统,表现出抗癌性质.
AMP激活蛋白激酶 (AMPK) 和刺 (STING) 途径调节巨细胞极化和瘤进展.

研究的目的:

研究在NSCLCTAM中AMPK和STING之间的监管关系.
阐明人参化物Re影响MΦ极化和NSCLC转移的机制.
在NSCLC免疫疗法中为金氏化物Re的抗转移作用提供机械学证据.

主要方法:

构造细胞培养和条件介质 (CM) 系统.
使用RT-PCR,西式涂抹,流细胞计和免疫光学来分析MΦ极化.
在小鼠模型中评估了金氏化物Re对TAM表型和瘤进展的影响.

主要成果:

在NSCLC TAM中确定了一个AMPKα1/STING正反循环,该循环驱动M2极化并促进NSCLC细胞迁移.
通过破坏AMPKα1/STING反循环,证明金氏胺Re可以抑制M2型的MΦ两极化.
表明,人参化物Re在体外抑制NSCLC细胞迁移和上皮-介质细胞过渡 (EMT),并在体内抑制瘤生长.

结论:

金色化物Re通过抑制AMPKα1/STING正反循环,有效调节MΦ两极化.
金色化物Re在NSCLC中表现出显著的抗转移效应.
金色化物Re具有作为NSCLC免疫疗法的治疗剂的潜力.

关键词:

它们是AMPKα1的.在NSCLCLC中,我们可以看到.刺痛是一种刺痛.人参化物 Re Re 巨细胞的两极分化

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