鱼类的心律不整是由环境条件的自然和人为变化引起的
Matti Vornanen1, Ahmed Badr1,2, Jaakko Haverinen1
1Department of Environmental and Biological Sciences, University of Eastern Finland, PO Box 111, 80101 Joensuu, Finland.
The Journal of experimental biology
|August 9, 2024
概括
污染物和温度变化等环境压力因素会导致鱼类心律失常. 心房静脉阻塞是最常见的心律失常,影响鱼类的心脏功能,并可能成为人类心脏研究的模型.
科学领域:
- 心血管生理学心血管生理学
- 环境毒理学环境毒理学
- 比較心臟病學 比較心臟病學
背景情况:
- 正常的心跳对于脊椎动物的平衡至关重要.
- 鱼类的心脏功能容易受到环境压力因素的影响,如污染物,缺氧和极端温度.
- 心律不整会扰乱正常的心脏功能,影响整体健康.
研究的目的:
- 审查鱼类心律失常的分子基础和功能后果.
- 整合鱼类心脏激发 - 收缩合和心律失常机制的知识.
- 探索鱼类作为人类心律不整的模型的潜力.
主要方法:
- 关于鱼类心脏电生理学和心律失常的现有文献的综述.
- 对鱼类心脏刺激 - 收缩合背后的分子机制的分析.
- 汇编了由环境因素引起的鱼类心律失常的数据.
主要成果:
- 鱼类心律不整,特别是心阻塞,是由热应激和有毒物质引起的.
- 在鱼类中,早期和延迟的脱极化比内热生物更少.
- 通过 sarcolemma 流入的比鱼心中的 sarcoplasmic reticulum 释放更为重要.
- 环境因素和毒素会损害鱼的心脏功能和承受压力的能力.
结论:
- 环境变化和离子通道毒素会诱导鱼类心律失常,降低它们的弹性.
- 鱼类心律不整,尤其是心阻塞,为心血管调节提供了洞察力.
- 尽管与内热体不同,但鱼心为人类心律不整提供了有价值的翻译模型,特别是在新生儿中.
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