在人类感染后复原的非类型型型沙门氏菌中,通过等离子体介导的阿兹罗密辛耐药性
Xi-Wei Zhang1, Jing-Jie Song1, Shi-Han Zeng1
1Department of Clinical Laboratory, Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
The Journal of antimicrobial chemotherapy
|August 9, 2024
概括
研究了非伤寒型沙门氏菌 (NTS) 抗阿兹胺素的机制. 耐亚胺素的NTS分离物携带了mph (A) 基因在等离体上,促进了多药性耐药性传播和限制了治疗选择.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 非伤寒型沙门氏菌 (NTS) 是导致食物传播疾病的重要原因之一.
- 在NTS中抗阿兹胺素耐药性是一个新兴的公共卫生问题.
- 了解NTS抗胺素耐药性的遗传基础对于有效治疗至关重要.
研究的目的:
- 调查NTS分离物中阿齐思罗米耐药性的遗传机制和流行病学.
- 描述与阿齐思罗米辛耐药性相关的等离子体和移动遗传元件.
- 评估多药耐药性传播的可能性.
主要方法:
- 对457个NTS分离物的抗菌敏感性测试.
- 全基因组测序和生物信息学分析.
- 结合实验和外流表达试验.
主要成果:
- 十个NTS分离物 (2.8%) 呈现出阿齐思罗米辛耐药性 (MIC 128-512 mg/L) 和多药耐药性.
- 抗阿兹胺素的耐药性是由位于各种等离子体 (IncFIB,IncHI2,InFII,InC,InCI) 上的mph(A) 基因赋予的.
- 塑体上的IS26类1整体促进了多药性耐药性的传播,包括对西普罗夫洛克萨和塞夫的耐药性.
结论:
- 携带mph ((A) 和整体的等离子体的传播严重威胁着阿齐思罗米辛在治疗NTS感染中的有效性.
- 鉴定出的遗传元素有助于NTS中多药耐药性的传播.
- 需要有效的策略来打击NTS中抗生素耐药性的传播.
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