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Updated: Jun 20, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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探索2-硫烯胺核弹头作为烯胺替代物用于向的共价抑制:一个BTK故事

Ruxandra Moraru1, Beatriz Valle-Argos2, Annabel Minton2

  • 1School of Chemistry and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K.

Journal of medicinal chemistry
|August 9, 2024
PubMed
概括

研究人员开发了一种新的2 - 硫烯胺基基基因,作为烯胺核弹头的稳定替代品,用于向共价抑制剂 (TCI). 这种基因有效抑制布鲁顿氨酸激酶 (BTK),提高了选择性和稳定性.

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