早期生命暴露组和自闭症风险:母亲微生物组的作用?
Claudia M Di Gesù1, Shelly A Buffington1,2
1Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Gut microbes
|August 9, 2024
概括
自闭症谱系障碍 (ASD) 涉及复杂的遗传学,微生物和免疫力. 分析多学科数据的综合方法为有针对性的自闭症治疗和改善生活质量提供了新的希望.
科学领域:
- 神经发育障碍 神经发育障碍
- 遗传学和基因组学 遗传学和基因组学
- 微生物组研究 微生物组研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种高度遗传的神经发育状况.
- 数以百计的ASD风险基因在关键的分子通路上聚合.
- 目前对ASD的治疗策略仍然有限.
研究的目的:
- 探索遗传学,微生物和ASD免疫力的相互作用.
- 突出整合生理学在ASD治疗开发中的潜力.
- 审查最近关于基因x在ASD风险中的母体暴露基因相互作用的发现.
主要方法:
- 对大规模多学科数据的分析.
- 调查基因x母体暴露体相互作用.
- 检查宿主-微生物相互作用和免疫系统在ASD中的作用.
主要成果:
- 多omics数据提供了对ASD风险因素的机制性见解.
- 遗传敏感性与微生物因素,新陈代谢,表观遗传学和免疫相互作用.
- 基因x母体暴露基因相互作用影响子宫内发育和ASD风险.
结论:
- 综合生理学方法对于ASD治疗突破至关重要.
- 了解ASD病因学的进步为新的治疗方法铺平了道路.
- 未来的治疗方法可以显著改善自闭症患者的生活质量.
更多相关视频
相关概念视频
01:19Autism Spectrum Disorder
78
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
78
01:23Anatomy of the Intestines
71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
01:30Socioemotional Development during Infancy
52
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
52
01:20Gene-Environment Interactions
270
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
270
01:26Modeling in Therapy
61
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
61
01:29Psychological and Sociocultural Causes of Schizophrenia
81
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
81