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Updated: Jun 17, 2025

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溶酶体膜蛋白TMEM106B通过调节LAMP2A稳定性来调节造血干细胞和祖细胞的增殖和分化

Di Guo1, Hongbo Xiong1,2, Zhongcheng Yang1

  • 1Center for Human Genome Research, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Maternal and Child Health Hospital of Hubei Province, Women and Children's Hospital of Hubei Province, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|August 9, 2024
PubMed
概括

TMEM106B蛋白稳定LAMP2A,这对造血干细胞和原生细胞 (HSPC) 功能至关重要. 它的缺失会损害HSPC的增殖和淋巴细胞分化,揭示出血液形成的新机制.

关键词:
在LAMP2A中,使用LAMP2A在TMEM106B中使用.血液形成 血液形成造血干细胞和原始细胞 (HSPC)血液造血干细胞 (HSCs) 是一种干细胞.斑马鱼是一种斑马鱼.

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