血小板/高密度脂蛋白比率 (PHR) 预测肥胖患者的2型糖尿病:一项回顾性研究
Yazeed Alshuweishi1, Arwa Abudawood2, Dalal Alfayez2
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
血小板高密度脂蛋白比率 (PHR) 是一个有价值的炎症标志物. 增加的PHR水平可以预测肥胖个体的2型糖尿病 (T2D),提供一个经济有效的诊断工具.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 炎症研究 炎症研究
背景情况:
- 肥胖和2型糖尿病 (T2D) 正在加剧全球健康问题.
- 慢性低度炎症和免疫系统激活是肥胖和T2D的标志,预测疾病的进展.
- 血小板高密度脂蛋白比率 (PHR) 正成为潜在的炎症标志物.
研究的目的:
- 调查肥胖患者中PHR和T2D之间的关联.
- 在肥胖群体中评估PHR作为T2D的预测标志物.
主要方法:
- 一项涉及203名肥胖患者 (BMI ≥30 kg/m2) 的研究,分为非糖尿病肥胖患者和糖尿病肥胖患者组.
- 对并发症,基线特征,实验室数据和PHR水平的分析.
- 使用ROC曲线分析评估PHR的中位数,风险和诊断性能.
主要成果:
- 与非糖尿病肥胖患者相比,患有T2D的肥胖患者的PHR中位数显著更高 (p < 0.0001).
- 在T2D肥胖患者中,PHR升高与更高的空腹血糖 (FBG) 和HbA1c水平相关 (p <0.05).
- ROC分析显示,PHR在肥胖个体中对T2D预测的AUC为0.700 (p < 0.0001),截止值为6.96 (灵敏度为53.4%,特异性为76.1%). 增加的PHR与T2D风险增加了4.77倍 (p < 0.0001).
结论:
- 在肥胖人口中,PHR作为预测T2D的实用和经济性标记.
- 这些发现支持PHR在识别肥胖人口群中患2型糖尿病高风险的个人的实用性.
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