男性管道微生物群和男性不孕症
Giuseppe Grande1, Andrea Graziani1, Luca De Toni1
1Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35128 Padova, Italy.
Cells
|August 9, 2024
概括
男性生殖道的微生物群影响生育能力. 精液中的特定细菌转移,如增加的Prevotella或Pseudomonas,与不孕症相关,而减少的乳酸菌可能表明精液质量低下.
科学领域:
- 微生物学 微生物学
- 生殖健康 生殖健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 男性生殖道微生物群在生殖健康中起着重要作用.
- 这种微生物群的变化与不孕症和感染有关.
- 了解这些微生物变化对于评估男性生育能力至关重要.
研究的目的:
- 审查目前关于不孕男性精液微生物群变化的证据.
- 检查与男性生殖道感染和HPV相关的变化.
- 探索微生物群分析在诊断和管理男性不孕症方面的潜力.
主要方法:
- 这是对现有研究的叙述性回顾.
- 数据是从关于精液微生物群组成的研究中合成的.
- 分析的重点是特定细菌与生育指标之间的关联.
主要成果:
- 增加了Prevotella spp. 的发生. 这种疾病与橄动物精子症和与肥胖相关的动物精子症有关.
- 伪omonas spp. 这种类型的. 与阿斯动物精子症和橄动物精子症相关的增加.
- 减少的乳杆菌种类. (尤其是L. crispatus) 可能表明精液质量差,而L. iners的增加是精子度降低的危险因素.
- 前列腺炎显示乳酸菌减少和菌种增加.
- 感染HPV与增加的Fusobacteria spp.相关.
结论:
- 精液微生物群的组成在各种男性不孕症和感染中发生变化.
- 特定的细菌简介可以作为精液质量和生育问题的生物标志物.
- 益生菌干预措施需要对前列腺炎等疾病进行调查.
- "情侣生殖器微生物群"的概念值得进一步研究,因为有精子与阴道的相互作用.
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