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内微生物组:在重塑瘤微环境景观方面,是敌人还是朋友?

Athina A Kyriazi¹, Makrina Karaglani^2,3, Sofia Agelaki⁴

¹Laboratory of Experimental Oncology, Division of Surgery, School of Medicine, University of Crete, 71500 Heraklion, Greece.

|August 9, 2024

概括

瘤内存在的瘤内微生物组会影响癌症的发展. 本综述探讨了它在塑造瘤微环境 (TME) 中的复杂作用及其对瘤发生的影响.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
瘤微环境 (TME) 是指瘤的微环境.

背景情况:

微生物组在癌症中的作用及其与瘤微环境 (TME) 的交叉交互已被证实.
位于瘤内的瘤内微生物组是癌症研究的一个新兴领域.
它作为癌症发生的驱动者或旁观者的确切作用尚不清楚.

研究的目的:

阐明瘤内部微生物组在瘤发育中的复杂作用.
探索其对重塑TME的影响.
为了确定其促进瘤或抑制瘤的影响.

主要方法:

对内微生物组和TME相互作用的现有文献的综述.
对微生物组对六个专门的TME层的影响的分析:免疫,代谢,缺氧,酸性,机械和内置.
解读微生物组对瘤进展的影响.

主要成果:

内微生物组显著重塑了TME.
它影响特殊的微环境,影响瘤的发展.
微生物组作为一个管弦乐手,以多方面的方式重塑TME.

结论:

内微生物组通过调节TME在癌症发育中发挥着关键作用.
了解这些相互作用对于开发新型癌症疗法至关重要.
需要进一步的研究来完全解码微生物组对瘤发生的复杂影响.

关键词:

癌症癌症癌症癌症癌症免疫细胞免疫细胞代谢过程中的代谢.微生物组是一个微生物组.治疗疗法治疗疗法治疗疗法瘤微环境是一个微环境.

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The Tumor Microenvironment

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