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通过水热合成,增强贝中提取的纳米-酸的生物活性和机械性能

Shih-Ching Wu¹, Hsueh-Chuan Hsu¹, Wen-Hui Wu²

¹Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan.

Nanomaterials (Basel, Switzerland)

|August 9, 2024

概括

贝被用来通过热水合成制造纳米酸 (nHA). 这种生物材料显示出出色的生物活性,细胞增殖和机械性能,用于骨再生应用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
材料化学材料化学

背景情况:

纳米酸 (nHA) 在生物医学中至关重要,特别是在牙科和骨科领域作为骨替代品,因为它的骨质导电性.
贝为生物材料合成提供可持续和可访问的来源.

研究的目的:

用水热方法在不同时间内从贝中合成nHA.
评估合成的nHA的结构,组成,生物活性和机械性能.

主要方法:

来自贝的nHA在150°C的水热合成10分钟,1小时,6小时,12小时.
使用XRD,FE-SEM,FTIR和ICP-MS进行材料表征.
通过模拟体液浸泡和细胞培养研究 (附着和增殖) 来评估生物活性.
在1200°C烧结后对机械性能进行评估.

主要成果:

6小时后,水热合成产生了纳米级nHA,其尺寸比增加,并且具有突出的棒状形态.
来自的nHA含有碳酸盐和微量元素,类似于人类硬组织.
合成的nHA表现出极好的生物活性,在SBF中形成了类似骨的酸盐层.
在150°C下1小时合成的nHA (HT2) 显示出优异的细胞附着和增殖.
在烧结后,HT2陶表现出增强的微硬度 (5.65 GPa) 和破裂性 (1.23 MPa·m^0.5).

结论:

使用贝的热水合成是生产具有可调整形态和组成的nHA的有效方法.
合成的nHA具有卓越的生物活性,细胞兼容性和机械强度,与天然牙相比或超过.
这种可持续的方法为开发用于骨再生和牙科应用的先进生物材料提供了有希望的途径.

关键词:

生物活性生物活性细胞培养培养的细胞培养.热水反应反应的热水反应氧帕提特是一种氧帕提特.微硬度微硬度微硬度的贝,的贝.烧结烧结是因为烧结.

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