便calprotectin诊断水平梯度沿着小肠在患有克罗恩氏病的患者
Offir Ukashi1,2, Uri Kopylov1,2, Bella Ungar1,2
1Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Ramat Gan, Israel.
Journal of Crohn's & colitis
|August 9, 2024
概括
在克罗恩氏病 (CD) 中,便中calprotectin (FC) 水平沿小肠 (SB) 增加,对远端SB炎症的敏感性更高. 这表明FC可以在CD患者中绘制炎症拓图.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 生物标志物发现发现
背景情况:
- 便中的calprotectin (FC) 是结肠炎症的敏感标记物.
- 它在诊断小肠 (SB) 炎症,特别是沿着SB轴的实用性不太清楚.
- 有限的数据存在于克罗恩病 (CD) 中不同SB段的FC水平.
研究的目的:
- 在患有克罗恩病 (CD) 的患者中,沿整个小肠 (SB) 轴调查便calprotectin (FC) 的诊断水平.
- 评估FC水平与SB炎症的地形分布之间的相关性.
主要方法:
- 对5项涉及成年CD患者的前性研究进行了后期分析.
- FC水平与路易斯评分 (LS) 对SB炎症的不同细分的相关性,不包括结肠病.
- 接收器操作特征 (ROC) 分析,以确定SB炎症拓的诊断FC水平.
主要成果:
- 对于类似的炎症活动,FC水平从近端到远端的SB段显著增加 (LS ≥135).
- 此外,FC水平也从远端SB增加到结肠.
- 特定的FC切线被确定为轻微的近端/远端SB炎症和更显著的近端炎症.
结论:
- 便calprotectin (FC) 显示出作为克罗恩病 (CD) 活动的地形生物标志物的潜力.
- 在检测粘膜炎症时,FC灵敏度在近端至远端小肠 (SB) 轴上增加.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Inflammatory Bowel Disease II: Crohn's Disease
206
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
206
Serum Laboratory Studies, Stool Test, Breath Test
325
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
325
Inflammatory Bowel Disease I: Ulcerative Colitis
160
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
160
Chronic Bowel Disorders: Introduction
436
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
436


