长度研究艾滋病毒和毒素质脑炎或潜在的毒素质感染患者的认知功能
Monica M Diaz1,2, J Allen McCutchan2,3, Melanie Crescini4,3
1Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.
AIDS (London, England)
|August 9, 2024
概括
患有艾滋病毒 (PWH) 的人经历了毒素性脑炎 (TE) 显示持续的神经认知障碍 (NCI). 虽然整体认知变化在七年内是最小的,但TE组的处理速度与没有毒素等离子体感染的组相比有所改善.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 神经认知障碍 (NCI) 可能在与艾滋病毒相关的中枢神经系统 (CNS) 联合感染后持续存在,例如毒性质脑炎 (TE).
- 在艾滋病毒感染者 (PWH) 中,TE和潜伏性毒性质感染 (LTI) 的长期认知影响仍然基本上是未知的.
- 这项研究研究了TE对PWH神经认知功能的纵向影响.
研究的目的:
- 评估艾滋病毒感染者 (PWH) 中毒素性脑炎 (TE) 的长期神经认知影响.
- 为了比较PWH的认知功能与TE病史,潜伏性毒性质感染 (LTI) 或没有毒性质感染.
- 在7年的时间内评估神经认知功能的变化.
主要方法:
- 从两个队列中对345名艾滋病毒感染者 (PWH) 进行了长度研究.
- 进行了全面的神经认知评估和抗毒素免疫球蛋白G (IgG) 测试.
- 参与者被分为三个组:TE+,LTI+和LTI-.
主要成果:
- TE+组在基线和7年随访期间在多个认知领域表现出NCI的最高患病率.
- 患有TE的参与者不太可能具有无法检测的病毒载荷,并且CD4+细胞数量较低.
- 虽然整体认知变化在7年内在各组中是最小的和相似的,但TE+组的处理速度与LTI-组相比改善得更快.
结论:
- 艾滋病毒感染者 (PWH) 具有 TE 病史的人经历显著的神经认知障碍 (NCI),随着时间的推移而持续.
- 从基线到随访的认知变化是最小的,除了处理速度外,在不同组之间没有显著差异.
- 这些发现突显了TE对PWH认知健康的持久影响,强调了需要持续监测和管理的需要.
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