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相关概念视频

Desmosomes01:05

Desmosomes

5.3K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
5.3K
Anchoring Junctions01:03

Anchoring Junctions

3.7K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.7K
Adherens Junctions01:24

Adherens Junctions

4.7K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
4.7K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.6K
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

25.4K
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
25.4K
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

2.8K
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
2.8K

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相关实验视频

Updated: Jun 17, 2025

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
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Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

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德斯莫索姆成为焦点.

Navaneetha Krishnan Bharathan1, Alexa L Mattheyses2, Andrew P Kowalczyk1

  • 1Departments of Dermatology and Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA.

The Journal of cell biology
|August 9, 2024
PubMed
概括

德斯莫索姆是组织完整性至关重要的细胞结点. 先进的成像揭示了它们的分子组织和在感知机械应力的潜在作用,提供了对组织健康和疾病的见解.

科学领域:

  • 细胞生物学 细胞生物学
  • 生物化学 生化学
  • 生物物理学的生物物理.

背景情况:

  • 德斯莫索姆是重要的细胞-细胞粘合结,为组织提供机械抵抗.
  • 脱体缺陷与各种疾病有关,包括影响心脏和表皮的疾病.
  • 了解德斯莫索姆的结构和功能对于组织完整性和疾病研究至关重要.

研究的目的:

  • 为了提供一个历史概述的desmosome发现和研究.
  • 审查细胞成像技术如何提高我们对德斯莫索姆结构和功能的理解.
  • 介绍一个更新的desmosome分子组织模型,并探索新的功能.

主要方法:

  • 历史文献评论. 历史文献评论.
  • 分析各种细胞成像技术 (光显微镜,电子显微镜,超分辨率显微镜) 的研究结果.
  • 整合最近关于德斯莫索姆分子架构和有机体关联的研究.

主要成果:

  • 影像技术的进化逐渐揭示了desmosome的结构和功能.
  • 当代成像已经详细描述了分子秩序,3D架构,以及与内质网膜等有机体的相互作用.
  • 提出了一个更新的desmosome分子组织模型.

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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

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相关实验视频

Last Updated: Jun 17, 2025

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
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Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

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结论:

  • 德斯莫索姆是具有复杂分子组织的动态结构.
  • 德斯莫索姆可以充当信号中心,感知机械和其他细胞应力.
  • 对德斯莫索姆信号的进一步研究可能会揭示相关疾病的新治疗点.