在成年人中代谢健康的肥胖症与X相关的低酸血症
Anne-Lise Lecoq1, Katharina Schilbach2, Laurence Rocher3
1Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate, 94 276 Le Kremlin Bicêtre Cedex, France.
European journal of endocrinology
|August 9, 2024
概括
超重和肥胖是常见的成年人与X链接的低酸血症 (XLH),与增加的脂肪质量相关. 然而,葡萄糖代谢异常并不比健康个体更普遍,这表明代谢健康的肥胖症.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 遗传学 遗传学 是一个
背景情况:
- 与X结合的低酸血症 (XLH) 涉及纤维细胞生长因子23 (FGF-23) 的升高,导致酸盐浪费和矿化缺陷.
- 流行病学数据表明,FGF-23与肥胖和代谢功能障碍之间存在联系.
- 患有XLH的儿童患有超重和肥胖的患病率很高.
研究的目的:
- 确定患有XLH的成年人中肥胖和相关代谢并发症的患病率.
- 为了研究成年XLH患者的身体组成和葡萄糖平衡.
主要方法:
- 一项前性队列研究包括来自第三级推中心的113名成人XLH患者.
- 评估了身体质量指数 (BMI),身体脂肪百分比 (FM%) 和脂肪组织分布.
- 葡萄糖平衡在一个小组中通过口服葡萄糖耐受性测试进行评估,并与匹配的对照组进行比较.
主要成果:
- 56%的XLH患者超重或肥胖 (平均BMI为25.3kg/m2).
- 体重指数与增加的体脂量和脂肪组织储存相关.
- 与对照组相比,没有发现快食葡萄糖受损,葡萄糖耐受性受损或糖尿病患病率的显著差异.
结论:
- 患有XLH的成年人有超重和肥胖的高患病率,与多余的脂肪质量有关.
- 尽管肥胖率很高,但XLH患者没有增加葡萄糖平衡异常的患病率.
- 在这个XLH成年人群中,代谢健康的超重或肥胖似乎占主导地位.
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