大麻素对风湿性疼痛的难以捉摸的真相
Hance Clarke1,2,3, Sarah Miles4, Miki Peer4
1Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada.
Current rheumatology reports
|August 9, 2024
概括
医用大麻 (MC) 显示出缓解类风湿性疾病疼痛的潜力,但高质量的证据有限. 医疗保健提供者应讨论当前的证据,并管理患者使用MC缓解症状.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学是基于证据的医学.
背景情况:
- 医用大麻 (MC) 越来越多地用于缓解症状,绕过传统的药物批准途径.
- 肌肉骨疼痛是使用MC的主要原因,特别是在类风湿性疾病患者中.
- 广泛的患者访问,通常没有医疗监督,需要审查MC在风湿病学中的作用.
研究的目的:
- 检查有关在患有类风湿性疾病的患者中使用医用大麻 (MC) 的现实问题.
- 为使用MC的风湿病患者的临床护理提供指导.
- 审查当前关于MC治疗风湿病的有效性和安全性的证据.
主要方法:
- 审查现有的受控临床研究,观察性队列研究和调查.
- 分析临床前数据和正在进行的临床试验.
- 关于MC化合物,施用途径和患者群体的证据综合.
主要成果:
- 有限的高质量的临床证据表明MC在类风湿性疾病中的有效性.
- 观察数据表明,使用MC可以改善疼痛和症状,但可能会导致轻度至中度的副作用.
- 相互矛盾的证据有助于患者和从业人员对关联性肌痛的MC产生不确定性.
结论:
- 尽管有前临床和观察发现很有希望,但在风湿性疾病中缺乏强有力的MC临床证据.
- 许多临床试验正在进行中,这可能会在未来十年澄清MC的作用.
- 医疗保健专业人员必须保持有关大麻素证据的了解,无偏见地沟通,并在涉及MC的患者护理中进行合作.
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