生物制剂在多发性肌痛风湿症中的有效性和安全性:一项回顾性研究
Naoaki Ohkubo1, Yusuke Miyazaki1, Shingo Nakayamada1
1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, Fukuoka, 807-8555, Japan.
Rheumatology and therapy
|August 9, 2024
概括
干白素-6受体抑制剂 (IL-6Ri) 可以有效地治疗多发性肌痛性风湿症 (PMR) 与类风湿性关节炎 (RA) 并发症. 这项研究发现,与其他生物修饰性抗风湿药物 (bDMARDs) 相比,IL-6Ri显著降低了疾病活性评分.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性肌痛性风湿症 (PMR) 可以与类风湿性关节炎 (RA) 发生重叠.
- 在PMR/RA病例中,葡萄糖皮质激素耐药性或不耐受性很常见.
- 生物修饰性抗风湿药物 (bDMARDs) 用于复杂的PMR/RA.
研究的目的:
- 评估bDMARDs在PMR患者的疗效和安全性.
- 为了比较治疗PMR/RA的不同类别的bDMARDs.
- 确定影响PMR/RA患者治疗结果的因素.
主要方法:
- 用bDMARDs治疗的203名PMR/RA患者的分析.
- 主要终点:26周临床多肌痛风湿性活动评分 (Clin-PMR-AS).
- 二级终点:不良事件的监测.
- 瘤坏死因子抑制剂 (TNFi),IL-6受体抑制剂 (IL-6Ri) 和CTLA4-Ig的比较.
主要成果:
- IL-6Ri的使用与26周的Clin-PMR-AS得分显著降低有关.
- 与TNFi (12.4) 和CTLA4-Ig (15.9) 相比,IL-6Ri显示了较低的Clin-PMR-AS平均值 (9.0).
- 体重指数,之前的bDMARD病史和IL-6Ri使用是Clin-PMR-AS.的重要因素.
结论:
- 介素-6受体抑制剂 (IL-6Ri) 显示出在PMR/RA中改善疾病活性的潜力.
- 对于患有RA的PMR患者来说,IL-6Ri可能是一个更有效的bDMARD选择.
- 对PMR/RA的IL-6Ri进行进一步研究是有必要的.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
124
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
124
Myasthenia Gravis: Overview and Treatment
1.3K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.3K
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K


