在怀孕期间和新生儿中,母亲的不良童年经历和生物衰老
Christian K Dye1, Daniel M Alschuler2, Haotian Wu1
1Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York.
JAMA network open
|August 9, 2024
概括
母亲的不良童年经历 (ACE) 与怀孕期间的表观遗传衰老有关. 这项研究没有发现ACEs影响新生儿表观遗传妊娠年龄加速的证据.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 童年不良经历 (ACE) 是18岁之前的创伤事件.
- ACE与表观遗传衰老和潜在的代际影响有关.
- 了解ACE跨代的生物嵌入对于公共卫生至关重要.
研究的目的:
- 研究生命经验的生物嵌入在几代人的传递.
- 分析母亲的ACE和母亲和新生儿的表观遗传钟之间的关联.
- 探索母体ACEs对母体和后代表观遗传衰老的影响.
主要方法:
- 采用阿文长度研究的父母和儿童 (ALSPAC) 和其ARIES子研究的数据进行横截面研究.
- 分析883个母婴二与DNA甲基化数据用于表观遗传年龄估计.
- 母亲ACE和产前抑郁症 (EPDS) 作为暴露;表观遗传年龄加速 (EAA) 和妊娠年龄加速 (GAA) 作为结果.
主要成果:
- 较高的母体ACE得分与怀孕期间母亲的GrimAgeEAA增加有关 (β=0.22,P<.001).
- 产前抑郁症也与更高的母体GrimAgeEAA (β=0.06,P=.01) 相关.
- 在母体ACE和新生儿GAA之间没有发现显著的关联.
结论:
- 母亲的ACE可能与怀孕期间的表观遗传衰老有关.
- 研究结果表明,母体ACE在后代发育和长期健康方面可能发挥作用.
- 需要进一步的研究才能充分理解与ACE相关的代际表观遗传传播.
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