评估短期和长期的氧化治疗对心电图参数的评估
Seyit Uyar1, Mehmet Kök1, Ayşe Ayan1
1Department of Internal Medicine, University of Health Sciences, Antalya Training & Research Hospital, Turkey.
在COVID-19患者中使用氧化 (HCQ),特别是使用勒沃素,显著延长了QTc间隔. 斯约格伦综合征的长期HCQ没有显著的QTc变化,突出显示了上下文依赖的安全性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 尽管安全数据有限,但在COVID-19大流行期间,氧化 (HCQ) 已被广泛使用.
- HCQ对心脏电生理学的影响,特别是与联合使用的药物的影响,需要进行彻底的调查.
研究的目的:
- 评估氧化 (HCQ) 对心电图 (ECG) 参数的急性和慢性影响.
- 评估阿齐思罗米和莱沃素联合给药对HCQ在COVID-19患者心脏安全概况的影响.
- 为了比较HCQ在Sjogren综合征患者的长期心脏安全性与其在COVID-19中的急性影响.
主要方法:
- 在109名接受HCQ治疗的COVID-19患者 (含或不含阿齐思罗米/莱沃素) 和51名长期接受HCQ治疗的斯乔格伦综合征患者中,对ECG参数的回顾性分析.
- 与109名不接受HCQ的COVID-19患者的对照组对QTc间隔变化的比较.
- 评估HCQ单一治疗与阿齐思罗米和勒沃素联合治疗.
主要成果:
- 在COVID-19患者中,HCQ单独治疗和与勒沃素联合治疗显著延长了QTc间隔.
- 与levofloxacin相比,同时使用HCQ和阿齐思罗米对QTc延长的效果较小.
- 在Sjogren综合征患者的长期HCQ治疗没有导致显著的QTc间隔延长.
结论:
- 氧化 (HCQ) 的心脏安全概况取决于情境,受治疗环境,同时服用的药物和患者因素的影响.
- 在COVID-19等急性情况下,谨慎使用HCQ是必不可少的,因此需要对心电图进行警监测,并考虑药物相互作用.
- 在COVID-19中短期使用HCQ与在Sjogren综合征等疾病中长期使用相比,具有不同的电生理风险.
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