连续皮下输注中药物添加剂的兼容性:优先进行常见组合的实验室测试
Marco Cheok In Leong1, Natasha Michael2,3, Robert Wojnar1
1Department of Pharmacy, Cabrini Health, Malvern, VIC, 3144, Australia.
在息治疗中,许多连续皮下输液 (CSCI) 缺乏兼容性数据,从而危及患者的安全. 这项研究确定了需要进行实验室测试的常见CSCI添加剂,以确保安全有效的药物使用.
科学领域:
- 抚慰性护理医学 抚慰性护理医学
- 制药复合剂 制药复合剂
- 临床药房 临床药房
背景情况:
- 当口服药物管理不可行时,持续皮下输注 (CSCI) 是至关重要的,特别是在息治疗中.
- 许多在临床实践中使用的CSCI添加剂的基于证据的兼容性数据存在重大差距.
- 缺乏兼容性数据可能会导致不理想的患者结果和潜在的安全问题.
研究的目的:
- 为了确定没有支持实验室兼容性数据的CSCI添加剂的使用频率.
- 为了确定最常见的处方添加剂缺乏兼容性证据.
- 为指导未来的CSCI添加剂实验室测试的优先设定.
主要方法:
- 在澳大利亚维多利亚州的五个息护理服务中,对CSCI的电子或纸质药物表进行了回顾性审查.
- 数据包括药物组合,剂量,稀释剂,体积,输液持续时间和报告的不良事件.
- 总共分析了616次输液,包括两到三种药物.
主要成果:
- 只有60%的评估的CSCI添加剂得到了实验室兼容性数据的支持.
- 在研究期间,发现11种常见的添加剂缺乏实验室兼容性数据.
- 这突显了大量的添加剂在没有经过验证的安全数据的情况下使用.
结论:
- 对已识别的常见CSCI添加剂进行实验室测试是非常需要的.
- 倡导这种测试将增强在息治疗中安全有效的药物管理.
- 优先考虑这些添加剂的兼容性研究对于改善临床实践至关重要.
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