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花启发的微粒具有高效的药物输送到深肺的药物
Huan Sun1, Shen Yan1, Chaojie Wu1
1Suzhou Key Laboratory of Green Chemical Engineering, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
灵感来自于公英的新型微粒子增强了药物向肺部的输送. 这些活性药物成分 (API) 嵌入干粉 (AeDPI) 改善肺部沉积,用于治疗诸如肺阿斯伯吉洛症等感染.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 活性药物成分 (API) 嵌入式吸入干粉 (AeDPI) 为肺部感染治疗提供高药物负载.
- 目前的AeDPI配方在实现高效的气泡膜沉积方面面临着挑战.
研究的目的:
- 使用喷雾冷干燥开发一种类似英的新型AeDPI微粒结构.
- 为了提高高剂量药物用于肺部感染的气泡沉积效率.
主要方法:
- 通过喷雾冷干燥制造AeDPI微粒的制造,灵感来自 dandelion结构.
- 使用伊特拉科纳 (ITZ) 作为模型API和TPGS作为稳定的纳米晶悬浮物的表面活性剂.
- 系统地调查配方参数和冷条件的微粒物质和气溶性能.
- 响应表面方法 (RSM) 的应用,以优化深肺沉积.
主要成果:
- 成功制造出具有增强结构完整性的 dandelion-like AeDPI 微粒.
- 最佳的微粒子配方实现了高细颗粒分数 (FPF) ~68.96%和超细颗粒分数 (eFPF) ~36.87%.
- 从10毫克的剂量中,大约4.60毫克和2.46毫克的药物分别到达肺部和气泡.
结论:
- 类似英的AeDPI微粒结构显著提高了药物输送到深肺的效率.
- 喷雾冷干燥是一种有效的技术,用于创建这些先进的微粒子配方.
- 这种方法有望改善治疗需要高剂量药物输送的肺部感染.
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