用菜种子和基于Bacillus的益生菌养的 brojlers中的免疫调节和 cecal微生物组变化
Deependra Paneru1, Guillermo Tellez-Isaias2, Walter G Bottje2
1Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.
Poultry science
|August 9, 2024
概括
草种子和基于Bacillus的直接养微生物可以减少 brojlers中的炎症标志物. 它们的组合协同调节肠道免疫力和微生物种群,增强肉的健康,不需要抗生素.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 密集的肉生产面临肠道疾病的挑战,需要替代抗生素增长促进剂.
- 提高肉肠道健康和免疫力对于可持续的全球粮食安全至关重要.
- 草种子 (FS) 和直接养微生物 (DFM) 的潜在益处正在被探索中.
研究的目的:
- 为了研究小松种子和基于Bacillus的DFM对 brojler ileal免疫基因表达的联合作用.
- 为了分析FS和DFM养的 brojlers中 cecal微生物种群的变化.
- 评估FS和DFM在调节肉肠道健康方面的协同潜力.
主要方法:
- 160只肉被分为四组:控制组,FS组,FS+DFM组和DFM组.
- 鸟类在42天内接受了含有或不含有5g/kg小松种子和/或0.1g/kg基于Bacillus的DFM的饮食.
- 在第42天进行了叶基因表达和叶微生物组分析.
主要成果:
- 无论是FS还是DFM,都单独降低了内炎症基因 (IL-6,IL-8L2,CASP6,PTGS2,IRF7) 的下调.
- 鸟类β-防御素基因调节是复杂的,需要进一步研究.
- Cecal微生物群的多样性是稳定的,但特定的种群,包括Clostridiales vadin BB60,被调节,特别是通过组合治疗.
结论:
- 草种子和基于Bacillus的DFM显示出降低炎症和改善肉免疫力的潜力.
- 结合FS和DFM,对免疫和微生物调节产生协同效应.
- 建议进行进一步的研究,包括病原体挑战模型,以充分了解综合益处.
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