在健康和疾病中,状体的整体感受
Silvia V Conde1, Fatima O Martins1, Joana F Sacramento1
1iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Autonomic neuroscience : basic & clinical
|August 9, 2024
概括
动脉体 (CB) 感知身体的内部状态,调节重要功能. 它的功能障碍与代谢疾病有关,这表明CB互感受的治疗点.
科学领域:
- 身体生理学 身体生理学
- 神经科学是一个神经科学.
- 代谢调节 代谢调节 代谢调节
背景情况:
- 内感觉,即对身体内部状态的意识,对于平衡至关重要.
- 动脉体 (CB) 是一个关键的感知器官,传统上感知血液气体和pH值.
- CB功能障碍与睡眠呼吸暂停,高血压和糖尿病有关.
研究的目的:
- 审查状体的传统和新型感官作用.
- 探索CB对代谢疾病的贡献.
- 提出针对CB代谢功能的治疗策略.
主要方法:
- 关于传统和新型CB功能的文献综述.
- 分析CB在代谢疾病病理生理学中的作用.
- 讨论针对CB互感受的治疗干预措施.
主要成果:
- 该CB感知氧气,二氧化碳和pH.
- 新出现的证据表明,CB检测血压,炎症和葡萄糖平衡的调解者.
- CB功能障碍有助于代谢疾病的发展.
结论:
- CB的感知功能超越了气体传感,扩展到代谢调节.
- 通过CB的功能障碍的代谢整体受体是代谢疾病的潜在因素.
- 针对CB的代谢性整体受体特性,为代谢障碍提供了一种新的治疗方法.
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