宫菌群,高风险HPV感染和宫癌:机制和治疗潜力
Roujie Huang1, Zimo Liu2, Tianshu Sun3
1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; The State Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Beijing 100730, China.
Microbiological research
|August 9, 2024
概括
变化的阴道和宫微生物群与高风险的人类乳头瘤病毒 (HPV) 感染和宫癌有关. 用益生菌和HPV疫苗恢复微生物平衡可能会提供新的治疗策略.
科学领域:
- 妇科瘤学 妇科瘤学
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
背景情况:
- 女人的生殖道是复杂的微生物群,对生殖健康至关重要.
- 微生物组失生症与各种疾病有关,包括人类乳头瘤病毒 (HPV) 相关的宫癌 (CC).
- 了解微生物群和HPV之间的相互作用对于开发新型治疗干预措施至关重要.
研究的目的:
- 在高风险HPV (HR-HPV) 感染和进展为宫癌期间审查宫-阴道和内微生物群的变化.
- 探索微生物群影响CC病变的机制,包括免疫调节,瘤基因表达和DNA损伤.
- 总结临床试验中关于益生菌,益生菌和HPV治疗疫苗的现有证据.
主要方法:
- 文献综述侧重于研究研究宫-阴道和内微生物群在HR-HPV感染和CC.
- 对微生物对宿主-病原体相互作用和癌症发展的影响机制的分析.
- 综合了评估基于微生物的干预措施的人体试验数据.
主要成果:
- 宫-阴道微生物群的失生与HR-HPV感染和CC发展有关.
- 微生物群体可以通过调节炎症,免疫反应,瘤基因表达,氧化应激和新陈代谢来产生致病或保护作用.
- 新出现的证据表明,益生菌,益生菌和益生菌载体HPV疫苗在清除HPV和改善细胞学异常方面具有潜力.
结论:
- 宫-阴道微生物群在HR-HPV相关的宫癌的发展和进展中发挥着重要作用.
- 准微生物失生症为针对宫癌的新型预防和治疗策略提供了一个有希望的途径.
- 对微生物调制的进一步研究有可能为HPV感染和CC的创新治疗提供潜力.
相关概念视频
01:18Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
01:27Cytotoxic T Cells-mediated Immune Response
861
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
861
01:30Cancer Vaccines
347
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
347
01:10Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:24Disorders of the Female Reproductive System
340
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
340