创伤类型对威胁条件和其灭绝的神经机制的影响
B Isabel Moallem1, Zhenfu Wen1, Mira Z Hammoud1
1Department of Psychiatry, School of Medicine, New York University, New York, NY, 10016, USA; Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, TX, 77054, USA.
Journal of psychiatric research
|August 9, 2024
概括
暴力创伤会影响涉及感知和注意力的脑网络,而非暴力创伤会影响情绪调节的学习. 性创伤特别影响与内部感知相关的领域.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 创伤研究 创伤研究
背景情况:
- 创伤类型影响临床症状,但其对神经情绪调节的影响尚不清楚.
- 了解创伤的神经影响对于有针对性的干预至关重要.
- 以前的研究往往将各种创伤经历归为组,限制了具体的见解.
研究的目的:
- 调查暴力与非暴力创伤如何不同地影响恐惧调节和灭绝的神经相关物.
- 为了检查性与非性暴力创伤的独特神经影响.
- 为了将神经活动和连接性与临床症状相关联.
主要方法:
- 来自三项研究的综合心理生理学 (皮肤导电反应 - SCR) 和功能磁共振成像 (fMRI) 数据.
- 分类创伤为暴力 (性/非性) 或非暴力.
- 在恐惧调节/灭绝过程中分析了SCR和fMRI数据,用于特定区域和全脑激活和连接.
主要成果:
- 暴力创伤组在灭绝回忆期间显示出更高的SCR.
- 非暴力创伤组在晚期灭绝学习期间表现出更大的功能激活.
- 暴力创伤组在默认模式网络 (DMN) 和前对对面控制网络中表现出更强的功能连接.
- 性创伤组在晚期灭绝学习期间在前额皮质和前皮质中显示出更高的激活.
- 非性创伤组在灭绝回忆期间在岛屿皮质中显示出更高的激活.
结论:
- 暴力创伤会影响大脑感知和注意的区域,而不是情绪调节区域.
- 性创伤会影响与内部感知相关的大脑区域.
- 创伤类型显著影响恐惧处理和情绪调节的神经基础.
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