曼吉费林在高温下捕获单个或多个活性碳烯物种
Ruoying Du1, Yu Liang1, Bo Si2
1Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2(#) Xuelin Road, Nanjing, 210023, PR China.
Food chemistry
|August 9, 2024
概括
曼吉费林有效地捕获反应性碳基物种 (RCS),如阿克罗莱因,甲基甘和甘,形成添加物. 它的捕获能力有所不同,这对抑制慢性疾病发展有影响.
科学领域:
- 食品化学 食品化学
- 生物化学 生物化学
- 分析化学 分析化学
背景情况:
- 反应性碳类物种 (RCS),包括阿克罗莱因 (ACR),甲基甘 (MGO) 和甘 (GO),由于它们的积累,与慢性疾病有关.
- 了解自然化合物与RCS的相互作用对于制定预防策略至关重要.
研究的目的:
- 在高温下研究曼吉费林 (MGF) 与ACR,MGO和GO的捕获能力和反应途径.
- 为了确定MGF单个和多个RCS的捕获能力的顺序.
- 阐明MGF-RCS添加物的形成机制及其抑制活性.
主要方法:
- 使用超高性能液体染色学-质谱学 (UPLC-MS/MS) 来分析MGF-RCS相互作用.
- 合成并确定了MGF-ACR和MGF-MGO adducts的结构.
- 在真实食物矩阵 (咖啡叶茶,蛋糕) 中验证了MGF的捕获能力和途径.
主要成果:
- 曼吉费林证明了捕获ACR,MGO和GO的能力,形成了不同的 adducts.
- 单个RCS的捕获效率顺序:ACR > MGO > GO.
- 多个RCS的捕获效率顺序:MGO > ACR > GO.
- MGF-ACR-MGO adduct形成涉及MGO被MGF-ACR捕获,这表明对MGO的抑制活性更高.
结论:
- 曼吉费林有效地清除反应性碳类物种,效率因RCS和反应条件而异.
- 这项研究提供了关于曼吉费林对抗RCS诱导损伤的保护机制的见解.
- 这些发现支持曼吉费林作为一种功能成分的潜力,可以减轻加工食品中与RCS相关的健康风险.
相关概念视频
Radical Oxidation of Allylic and Benzylic Alcohols
1.9K
Activated manganese(IV) oxide can selectively oxidize allylic and benzylic alcohols via a radical intermediate mechanism. Primary allylic alcohols are oxidized to aldehydes, while secondary allylic alcohols yield ketones. The redox reaction of potassium permanganate with an Mn(II) salt such as manganese sulfate (under either alkaline or acidic conditions), followed by thorough drying, yields the oxidizing agent: activated MnO2. While MnO2 is insoluble in the solvents used for the reaction, the...
1.9K
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
1.9K
The radical dimerization of ketones or aldehydes gives vicinal diols through a pinacol coupling reaction. However, the behavior of titanium metals used for the reaction as a source of electrons is unusual. When the reaction is carried out in the presence of titanium, diols can be isolated at low temperatures. Else titanium further reacts with diols, forming alkenes through the McMurry reaction.
1.9K
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate
11.2K
Alkenes can be dihydroxylated using potassium permanganate. The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
11.2K
Reactions of Aldehydes and Ketones: Baeyer–Villiger Oxidation
4.1K
Baeyer–Villiger oxidation converts aldehydes to carboxylic acids and ketones to esters. The reaction uses peroxy acids or peracids and is often catalyzed by acid. The reaction is named after its pioneers, Adolf von Baeyer and Victor Villiger. The reaction is achieved by a wide range of peracids such as m-chloroperoxybenzoic acid (mCPBA), perbenzoic acid (C6H5COOOH), peracetic acid (CH3COOOH), hydrogen peroxide (H2O2), and tert-butyl hydroperoxide (t-BuOOH).
The carbonyl center is...
The carbonyl center is...
4.1K
Oxidation of Alcohols
12.9K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
The process of oxidation in a chemical reaction is observed in any of the three forms:
12.9K
Oxidations of Aldehydes and Ketones to Carboxylic Acids
3.8K
Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
3.8K


