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乳腺癌患者新辅助化疗期间的适度体力活动:对与癌症相关的炎症和病理完整反应的影响-Neo-Runner研究
O Garrone1, M Paccagnella2, A Abbona3
1Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
ESMO open
|August 9, 2024
概括
适度体力活动 (mPA) 与新辅助化疗 (NACT) 结合,可降低炎症并改善乳腺癌患者的病理完整反应 (pCR) 率. 这项研究强调了在癌症治疗期间运动的好处.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 运动科学 运动科学
背景情况:
- 众所周知,身体活动 (PA) 可以降低乳腺癌 (BC) 风险和死亡率.
- 中度PA (mPA) 可能在新辅助化疗 (NACT) 期间调节免疫系统.
- 有限的数据存在于mPA在NACT期间的免疫调节.
研究的目的:
- 为了研究单独使用NACT与与mPA结合使用NACT期间细胞因子的纵向变化.
- 评估mPA对接受NACT的BC患者炎症和治疗反应的影响.
主要方法:
- 在92名BC患者中,在四个时间点 (T0-T3) 测量了23种细胞因子.
- 患者接受了单独的NACT (未经训练,n=21) 或NACT与mPA (经过训练,n=71).
- mPA涉及每3周快速行走9-10周;计算了细胞因子评分 (CS).
主要成果:
- 单独使用NACT就改变了细胞因子配置,对IL-5,IL-6,IL-15,CCL-2,IFN-γ,CXCL-10进行上调,对IL-13,CCL-22进行下调.
- 结合的NACT和mPA进一步调节细胞因子,增加IL-21,CCL-2,TNF-α,并减少IL-8,IL-15,VEGF,sIL-6R.
- 经过训练的患者表现出降低的CS (减少炎症) 和更高的病理完整反应 (pCR) 率 (78%与未经训练的22%相比).
结论:
- mPA与NACT相互作用以减少炎症,经过训练的患者的细胞因子评分下降表明了这一点.
- 这种mPA的免疫调节作用可能有助于在运动患者中观察到的显著更高的pCR率.
- 将mPA整合到NACT疗法中可能是改善乳腺癌治疗结果的有益策略.
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