在COVID-19患者的内合规性:一个多中心观察性研究
Ana Flávia Silveira1, Marcella Barreto Santos2, Nelci Zanon Collange2,3
1Universidade Federal de São Carlos, Departamento de Fisioterapia, São Carlos SP, Brazil.
Arquivos de neuro-psiquiatria
|August 9, 2024
概括
在COVID-19患者的机械通风 (MV) 与其他诊断相比没有影响内合规性 (ICC). 然而,在MV的COVID-19患者显示出比MV的患者更高的ICC,这表明COVID-19本身不会影响ICC.
科学领域:
- 神经学 神经学
- 临界护理医学 临界护理医学
- 肺部病理学 肺部病理学
背景情况:
- 严重的COVID-19通常需要侵入性机械通风 (MV),可能会影响内压力 (ICP) 和内合规性 (ICC).
- 之前的研究将积极的MV参数与神经系统疾病中的ICP变化联系起来,但对非神经系统患者的影响仍未评估.
- 了解MV在COVID-19中对ICC的影响对于管理重症患者至关重要.
研究的目的:
- 将机械通风COVID-19患者的ICC与其他诊断进行比较.
- 通过将非MV COVID-19 患者与健康对照进行比较,评估COVID-19 对ICC的孤立影响.
- 描述MV和COVID-19对内合规性的综合影响.
主要方法:
- 一项探索性观察性研究,利用78名参与者的方便样本.
- 在使用P2/P1比率进行非侵入性评估的内合规性 (ICC),其中P2>P1表明异常的ICC.
- 统计分析采用带有随机效应的混合线性模型来比较四组的ICC:MV-COVID-19,MV非COVID-19,非MV COVID-19,和健康对照.
主要成果:
- 在MV COVID-19和MV非COVID-19患者之间没有发现P2/P1比率的显著差异.
- 同样,在非MVCOVID-19患者和健康志愿者之间,没有观察到P2/P1比率的差异.
- 与没有MV的COVID-19患者相比,需要MV的COVID-19患者的P2/P1比率更高.
结论:
- 这项研究表明,COVID-19感染本身并不会本质上损害内合规性 (ICC).
- 研究结果表明,机械通风可能会影响COVID-19患者的ICC,而不管底层诊断是什么.
- 需要进一步的研究,以充分阐明COVID-19,机械通风和脑血管血液动力学之间的复杂相互作用.
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