在cystargolide和belactosin生物合成中解读SAM和O-甲基转移酶的金属依赖机制:一个结构-活性关系研究研究

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Updated: Jun 17, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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Wolfgang Kuttenlochner1, Patrick Beller2, Leonard Kaysser3

  • 1Department of Bioscience, Center for Protein Assemblies (CPA), TUM School of Natural Sciences, Technical University of Munich, Garching, Germany.

The Journal of biological chemistry
|August 9, 2024
PubMed
概括

囊藻类和贝拉克索辛是抑制蛋白酶的天然产品,显示出癌症和神经退行性疾病治疗的潜力. 研究人员在他们的关键生物合成酶BelI和CysG中发现了一种保存的结合机制.

关键词:
酶机制的酶机制是什么金属离子蛋白相互作用分子对接的分子对接.自然产品的生物合成.结构-功能的结构-功能.

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