治疗割抗性前列腺癌的男性中的症状负担:一项纵向研究
Ulrika Rönningås1, Per Fransson2, Maja Holm3,4
1Department of Nursing, Umeå University, Umea, Sweden ulrika.ronningas@rvn.se.
BMJ supportive & palliative care
|August 9, 2024
概括
患有转移性割抵抗性前列腺癌 (mCRPC) 的男性在延长生命治疗的第一年经历了身体症状和整体症状负担的显著增加. 心理症状负担保持稳定.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 患者报告的结果
背景情况:
- 转移性割抵抗性前列腺癌 (mCRPC) 治疗正在扩大,但在现实环境中理解长期症状负担是有限的.
- 症状管理对于改善正在接受治疗的mCRPC男性的生活质量至关重要.
- 很少有研究在mCRPC生命延长治疗的最初一年中纵向评估了多维症状负担.
研究的目的:
- 为了研究mCRPC患者在生命延长治疗的第一年多维症状负担的变化.
- 分析mCRPC患者在治疗期间体验的身体,心理和症状数量.
主要方法:
- 分析了134名在生命延长治疗的第一年患有mCRPC的男性的纵向数据.
- 使用纪念症状评估量表来评估症状.
- 使用线性混合建模来分析身体,心理和症状数量的变化.
主要成果:
- 在研究的一年中,症状的平均数量从大约10个增加到12个.
- 缺乏能量和出汗是最普遍的症状;性问题引起了最高的痛苦.
- 随着时间的推移,身体症状负担和症状总数显著增加,而心理负担保持稳定.
结论:
- 在接受mCRPC治疗的男性中,身体症状负担需要更多的临床关注.
- 早期整合息治疗可以改善症状管理,提高mCRPC患者的生活质量.
- 需要进一步的研究来解决mCRPC治疗中不断变化的症状格局.
相关概念视频
Disorders of the Male Reproductive System
370
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
370
Menopause
146
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
146
Infertility in Males
256
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
256


