一位36岁的女性患有间歇性蓝症
Brandon W Moritz1, Fouad Chouairi2, Adam Tosh2
1Department of Internal Medicine, Duke University School of Medicine, Durham, NC; Department of Pediatrics, Duke University School of Medicine, Durham, NC.
Chest
|August 9, 2024
概括
一名患者因纳皮里丁的毒性而患上色症. 这一案例凸显了考虑阿片类药物使用障碍患者出现缺氧的药物副作用的重要性.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 阿片类药物使用障碍 (OUD) 是一种慢性复发性疾病.
- 频繁的尿路感染 (UTI) 在患有OUD的女性中很常见.
- 纳索皮里丁是一种尿路止痛药,可引起甲基红蛋白血症.
研究的目的:
- 在患有OUD的患者中报告一种以蓝色呈现的费纳索皮里丁诱导的甲基红蛋白血症病例.
- 强调在患者中考虑药物毒性的重要性,原因不明的缺氧.
主要方法:
- 一个36岁的女性患有OUD和频繁的尿路感染的病例报告.
- 患者出现严重的缺氧 (Spo2 82%) 和色.
- 病史显示,在症状出现之前,新发症的费纳索皮里丁使用.
主要成果:
- 患者的色和缺氧归因于由费纳索皮里丁毒性引起的甲基红蛋白血症.
- 甲和其他并发症被考虑,但被排除为主要原因.
- 停止服用费纳索皮里丁导致症状的消失.
结论:
- 费纳索皮里丁可以诱导甲基红蛋白血症,导致色和缺氧.
- 临床医生应在有相关药物病史的患者中保持对药物诱导的甲基红蛋白血症的高怀疑指数.
- 由于多种药物治疗,OUD患者的风险增加,可能导致药物不服药或滥用药物.
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