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对nortriptyline的止痛功能的定量分析:一个比较的系统审查和元分析

Soroush Hashemzadeh¹, Mohammad Mortazavi², Ramin Abdi Dezfouli³

¹Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Islamic Azad University of Medical Sciences, Tehran, Iran.

|August 9, 2024

概括

诺特利普提林在神经病变等疾病中有效减少疼痛,但在纤维肌痛或骨关节炎中没有. 这种三环抗抑郁药通常可以很好地耐受止痛药的使用.

科学领域:

药理学药理学是指药理学的学科.
疼痛管理疼痛管理
临床试验临床试验

背景情况:

三环抗抑郁药,如诺特林,越来越多地被用于非精神疾病.
它们的止痛性能和安全性质需要全面评估.

研究的目的:

量化分析诺特利普提林的止痛疗效,安全性和耐受性.
综合了临床试验中关于nortriptyline在各种疼痛条件下使用的证据.

主要方法:

发表的临床试验的系统审查和元分析.
使用标准化平均差异 (SMD) 和标准化平均变化 (SMC) 来提取和合成数据.
使用既定标准评估的偏见风险和证据确定性.

主要成果:

在慢性下背痛,主要抑郁症,神经病变,慢性盆腔疼痛和神经病性角膜疼痛中,诺特利普提林显著降低了疼痛.
与安慰剂相比,在纤维肌痛和膝关节骨关节炎中没有观察到显著的疗效.
聚合的SMD减轻疼痛是0.43与安慰剂相比和-0.18与替代止痛药相比;聚合的SMC是-1.20.
常见的副作用包括便秘和口腔干燥,但通常耐受良好.

结论:

诺特利普提林在特定的慢性疼痛条件,特别是神经病痛中表现出有效性.
它在止痛剂量下耐受良好,与其他治疗方法 (如阿米和 gabapentin) 相当.
它的效用因疼痛类型而异,在纤维肌痛和骨关节炎中表现出有限的有效性.

关键词:

临床药理学临床药理学慢性疼痛慢性疼痛慢性疼痛疼痛管理疼痛管理疼痛管理疼痛管理

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